Inhibition by griseofulvin of microtubule assembly in vitro
نویسندگان
چکیده
منابع مشابه
Inhibition by p-bromophenacyl bromide of microtubule assembly in vitro.
Introduction Microtubules (MTs) play a central role in a variety of cellular phenomena including cell division, cell morphology and intracellular transport [ 11. Pharmacological studies of MT function and assembly involve the use of a range of MT poisons. Such agents can disrupt the control of MT dynamics either by stabilizing, e.g. taxol [2, 31, or destabilizing e.g. MTs [4-71, usually through...
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Microtubules are dynamic cytoskeletal polymers present in all eukaryotic cells. In animal cells, they are organized by the centrosome, the major microtubule-organizing center. Many centrosomal proteins act coordinately to modulate microtubule assembly and organization. Our previous work has shown that Cep70, a novel centrosomal protein regulates microtubule assembly and organization in mammalia...
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This study investigates the inhibition of microtubule assembly in vitro by podophyllotoxin and its derivatives, which include in part the antitumor compounds 4'-demethylepipodophyllotoxin ethylidene beta-D-glucoside (VP-16-213) and 4'-demethylepipodophyllotoxin thenylidene beta-D-glucoside (VM-26); the cyclic ethers, cyclic sulfides, and cyclic sulfones of podophyllotoxin and deoxypodophyllotox...
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Chicks were injected intra-cerebrally with [(3)H]leucine, and (3)H-labeled microtubules were assembled in vitro in the brain supernatants. Pieces of these (3)H-labeled microtubules were then incubated with unlabeled brain tubulin subunits under conditions where the subunits assembled onto the labeled pieces. Electron microscopic autoradiography of the negatively-stained microtubules showed all ...
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Dr. Mundy is the recipient of a Faculty Research Award (FRA-148) from the American Cancer Society. Dr. Mundy's present address is Divison ofEndocrinology and Metabolism, Department of Medicine, University ofTexas Health Science Center, San Antonio, Tex. Received for publication 23 April 1979 and in revised form 29 August 1980. INTRODUCTION Osteolytic bone metastases are a frequent complication ...
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ژورنال
عنوان ژورنال: FEBS Letters
سال: 1976
ISSN: 0014-5793
DOI: 10.1016/0014-5793(76)80539-x